The known effects of those PTMs on ATXN2’s operate and SCA2 pathogenesis remains limited. In other polyQ illnesses, numerous research advised that proteolytic cleavage of polyQ proteins could Perform a crucial part in pathogenesis [36, 45]. Aligned with this strategy, the existence of the enriched 42 kDa fragment in the Mind https://alexu002kre3.atualblog.com/profile