Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts through the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have discovered recurrent mutations in genes regulating tumor mobile-microenvironment in... https://davidc086ygo3.wikimidpoint.com/user