There's a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors inside the dorsal horn to lessen afferent soreness transmission and generate analgesia. As a result, medications like clonidine that target alpha-two receptors can impact the transmission of soreness. Could possibly be provided as monotherapy https://brucep379tpj8.wikipowell.com/user