You will find there's release of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to lower afferent discomfort transmission and deliver analgesia. Thus, medication like clonidine that concentrate on alpha-2 receptors can influence the transmission of suffering. Can be supplied as monotherapy https://www.proleviate.com/post/the-new-pain-killer-conolidine