Very poor/Intensive Metabolizers, CYP2D6 The development in the active metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Roughly seven% of the populace has diminished action of the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme system. These persons are “poor metabolizers” of debrisoquine, dextromethorphan and tricyclic antidepressants, amid other drugs. https://vannevark774uah0.wikitron.com/user